For contemporary American audiences, the zither begins and ends with the soundtrack to the 1949 film The Third Man - which famously featured the instrument in its opening. (See the credits at http://www.youtube.com/watch?v=n4JpDUMXBqo.) The tune was a number-one hit in the United States in 1950.
But the stringed instrument has a rich history in Europe and Asia and dates back more than two millennia.