Steve Carell, Paul Rudd, Romany Malco, and Seth Rogen in The 40-Year-Old VirginTHE 40-YEAR-OLD VIRGIN

Considering the film's title, this might sound ludicrous. But in The 40-Year-Old Virgin, Steve Carell, playing our hapless hero Andrew, gives what might become a legendary comedic screen performance.

David Duchovny, Julianne Moore, Seann William Scott, and Orlando Jones in EvolutionEVOLUTION

The sci-fi comedy Evolution is like Ghostbusters without Bill Murray, which isn't surprising since both films were directed by Ivan Reitman, but it also means that it's like Ghostbusters without the big laughs. In that 1984 blockbuster, Murray delivered his lines with an italicized innuendo that made even his throwaway quips hilarious; without his presence, the film (and its underrated 1989 follow-up) would just have been a moderately pleasant, cheesy, overscaled, haphazardly paced affair. That's Evolution.